High Myopia refers to extreme or severe nearsightedness that occurs as the result of slightly elongated eyeball shape. Early onset high myopia is often found to be transmitted through families in Mendelian patterns, including autosomal dominant (AD), autosomal recessive (AR), and X-linked (XL) inheritance. Late-onset high myopia is generally transmitted as a complex trait.

The DBGen high myopia panel is focused on a myopia-candidate approach that includes the coding regions of 505 genes associated with corneal dystrophies, connective tissue diseases, retinal dystrophies, cataracts, ocular developmental abnormalities and reported genes responsible for isolated high myopia.